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Infection and Immunity, October 1999, p. 5477-5479, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Evidence That Cryptococcus neoformans Is
Melanized in Pigeon Excreta: Implications for Pathogenesis
Joshua D.
Nosanchuk,1
Joseph
Rudolph,1
Angel L.
Rosas,2 and
Arturo
Casadevall1,2,*
Department of Medicine (Division of
Infectious Diseases),1 and Department of
Microbiology and Immunology,2 Albert
Einstein College of Medicine, Bronx, New York 10461
Received 31 March 1999/Returned for modification 27 May
1999/Accepted 1 July 1999
Structures similar to the melanin "ghosts" of melanized
cryptococcal cells were isolated from pigeon excreta contaminated with
Cryptococcus neoformans, and their growth in pigeon excreta supported melanization. The results suggest that environmental C. neoformans cells are melanized and imply that initial infection may involve exposure to melanized cells.
*
Corresponding author. Mailing address: Department of
Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-4259. Fax: (718) 430-8968. E-mail: casadeva{at}aecom.yu.edu.
Infection and Immunity, October 1999, p. 5477-5479, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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