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Infection and Immunity, October 1999, p. 5480-5482, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Divergent Roles of Tumor Necrosis Factor and Platelet-Activating Factor in Endotoxin-Induced Release of Monocyte Chemoattractant Protein 1 and Macrophage Inflammatory Protein 1beta in Chimpanzees

Pascale E. P. Dekkers,* Marcel Levi, Sander J. H. van Deventer, and Tom van der Poll

Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, and Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands

Received 26 April 1999/Returned for modification 3 June 1999/Accepted 16 July 1999

A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1beta (MIP-1beta ) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1beta . Levels of MIP-1beta and MCP-1 release were differentially regulated during endotoxemia.

* Corresponding author. Mailing address: Laboratory of Experimental Internal Medicine, Rm. G2-105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5666034. Fax: 31-20-6977192. E-mail: P.E.Dekkers{at}AMC.UVA.NL.

Infection and Immunity, October 1999, p. 5480-5482, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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