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Infection and Immunity, October 1999, p. 5483-5485, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Growth Rate of Mycobacteria in Mice as an Unreliable Indicator of Mycobacterial Virulence

Robert J. North,* Lynn Ryan, Ronald LaCource, Tirsit Mogues, and Mariam E. Goodrich

The Trudeau Institute, Saranac Lake, New York 12983

Received 12 May 1999/Returned for modification 14 June 1999/Accepted 13 July 1999

The CDC1551 strain of Mycobacterium tuberculosis was compared with the H37Rv strain of M. tuberculosis and the Ravenel strain of Mycobacterium bovis for virulence in mice. Although all three strains gave rise to the same level of stationary infection in major organs, mice infected with the Ravenel strain died much earlier from lung disease.

* Corresponding author. Mailing address: The Trudeau Institute, 100 Algonquin Ave., Saranac Lake, NY 12983. Phone: (518) 891-3080. Fax: (518) 891-5126. E-mail: rjnorth{at}northnet.org.

Infection and Immunity, October 1999, p. 5483-5485, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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