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Infection and Immunity, October 1999, p. 5490-5494, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Tyrosine Phosphatase SHP-1 Is Involved in CD66-Mediated Phagocytosis of Opa52-Expressing Neisseria gonorrhoeae

Christof R. Hauck,1,2 Erich Gulbins,3 Florian Lang,3 and Thomas F. Meyer1,2,*

Max-Planck-Institut für Biologie, Abteilung Infektionsbiologie,1 and Physiologisches Institut, Universität Tübingen,3 72076 Tübingen, and Max-Planck-Institut für Infektionsbiologie, 10117 Berlin,2 Germany

Received 30 March 1999/Returned for modification 1 June 1999/Accepted 6 July 1999

Opa proteins of Neisseria gonorrhoeae bind to CD66 receptors on human phagocytes, thereby inducing efficient uptake of the bacteria in the absence of opsonins. The interaction of Opa proteins and CD66 receptors leads to activation of Src family tyrosine kinases, a process that is of critical importance for the efficient, CD66-mediated internalization. Here we show that during Opa-mediated stimulation of CD66 the activity of the host cell tyrosine phosphatase SHP-1 is strongly downregulated, concomitant with increases in the tyrosine phosphorylation of several cellular proteins. Since the SHP-1 tyrosine phosphorylation level itself is influenced by Opa-induced events, this phosphatase comprises an important regulatory checkpoint of the pathogen-triggered signaling cascade in human phagocytes.

* Corresponding author. Mailing address: Max-Planck-Institut für Infektionsbiologie, Abteilung Molekulare Biologie, Monbijoustr. 2, 10117 Berlin, Germany. Phone: 49-30-28 46 04 01. Fax: 49-30-28 46 04 02. E-mail: meyer{at}mpiib-berlin.mpg.de.

Infection and Immunity, October 1999, p. 5490-5494, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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