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Infection and Immunity, October 1999, p. 5538-5540, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Type III Secretion-Dependent Hemolytic Activity of Enteropathogenic Escherichia coli

Jonathan Warawa,1,2 B. Brett Finlay,2 and Brendan Kenny1,2,*

Department of Pathology and Microbiology, School of Medical Sciences, Bristol, England1 and Biotechnology Laboratory, Vancouver, British Columbia, Canada V6T 1Z32

Received 5 February 1999/Returned for modification 1 April 1999/Accepted 27 July 1999

Enteropathogenic Escherichia coli (EPEC) was found to exhibit a type III secretion-dependent, contact-mediated, hemolytic activity requiring the EspA, EspB, and EspD secreted proteins. EspB and EspD display homology to pore-forming molecules. Our data suggest a mechanism to explain the requirement for all three Esp proteins in the transfer of EPEC proteins, such as Tir, into target cells.

* Corresponding author. Mailing address: Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol, BS8 1TD, England. Phone: (0117) 928 7530. Fax: (0117) 930 0543. E-mail: B.Kenny{at}bristol.ac.uk.

Infection and Immunity, October 1999, p. 5538-5540, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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