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Infection and Immunity, October 1999, p. 5541-5544, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Alpha-Toxin Damages the Air-Blood Barrier of the Lung in a Rat Model of Staphylococcus aureus-Induced Pneumonia

Mary C. McElroy,1,2,* Helen R. Harty,2 Gayle E. Hosford,2 Gráinne M. Boylan,2 Jean-François Pittet,3 and Timothy J. Foster4

Rayne Laboratories, University of Edinburgh, Scotland1; Departments of Physiology2 and Microbiology,4 Trinity College Dublin, Dublin, Ireland; and Department of Anesthesia, University of California, San Francisco, California3

Received 26 April 1999/Returned for modification 9 June 1999/Accepted 9 July 1999

We have shown that injury to alveolar epithelial type I cells may account, in part, for damage to the air-blood barrier of the lung in a rat model of Staphylococcus aureus pneumonia. We have also shown that alpha-toxin is an important cause of damage to the air-blood barrier; however, our data suggest that the toxin is not acting directly on alveolar type I cells.

* Corresponding author. Mailing address: Rayne Laboratories, University of Edinburgh, Teviot Place, Edinburgh, Scotland EH8 9AG. Phone: 44 131 650 6949. Fax: 44 131 650 4384. E-mail: mmcelroy{at}ed.ac.uk.

Infection and Immunity, October 1999, p. 5541-5544, Vol. 67, No. 10
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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