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Infection and Immunity, November 1999, p. 6161-6163, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Binding of Pili from Uropathogenic Escherichia coli to Membranes Secreted by Human Colonocytes and Enterocytes

G. S. Goetz,1,dagger A. Mahmood,1 S. J. Hultgren,2 M. J. Engle,1 K. Dodson,2 and D. H. Alpers1,*

Departments of Internal Medicine (Division of Gastroenterology)1 and Molecular Microbiology,2 Washington University School of Medicine, St. Louis, Missouri

Received 16 April 1999/Returned for modification 10 June 1999/Accepted 3 August 1999

PapG adhesins mediate the binding of uropathogenic Escherichia coli. Although receptors for these adhesins have not been demonstrated in intestinal epithelia, the colonic microflora includes strains of uropathogenic E. coli. We now report that surfactant-like particles secreted by the human intestine contain receptors for PapG adhesins and may provide an intestinal habitat for uropathogenic bacteria.

* Corresponding author. Mailing address: Washington University School of Medicine, Campus Box 8124, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-8940. Fax: (314) 362-8959. E-mail: dalpers{at}imgate.wustl.edu.

dagger Present address: GI Division, University of Arkansas for Medical Sciences, Little Rock, AR 72205.

Infection and Immunity, November 1999, p. 6161-6163, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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