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Infection and Immunity, November 1999, p. 6177-6180, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Modulation of B-Lymphocyte and NK Cell Activities by Glycoinositolphospholipid Purified from Trypanosoma cruzi

Luciana B. de Arruda Hinds,1,2 Lucia Mendonça Previato,3 José Osvaldo Previato,3 Quirijn Vos,4 James J. Mond,4 and Ligia M. T. Peçanha1,*

Departments of Immunology1 and General Microbiology,3 Instituto de Microbiologia Prof. Paulo de Góes and Instituto de Biofísica Carlos Chagas Filho,2 Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil, and Division of Immunology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland4

Received 26 March 1999/Returned for modification 29 April 1999/Accepted 24 August 1999

Glycoinositolphospholipids (GIPLs) are some of the major glycolipids of the Trypanosoma cruzi surface that were previously shown to activate B cells. In the present study, we investigated whether (i) T. cruzi GIPLs could induce immunoglobulin secretion from B cells in the absence of T cells and NK cells and whether (ii) NK cells are also stimulated by the GIPLs. B cells purified from mice deficient in both T and NK cells (CD3varepsilon transgenic mice) secreted immunoglobulin in response to the GIPL. This response was increased by coculture with a murine NK cell line. The T. cruzi GIPL also increased the NK cell (interleukin-2 induced) proliferative response. Our data indicate that the T. cruzi GIPL has a direct stimulatory effect on NK cells and induces immunoglobulin secretion in the absence of T lymphocytes and NK cells. These findings suggest that this T. cruzi-derived molecule may be one of the stimulators that lead to NK cell activation during T. cruzi infection.

* Corresponding author. Mailing address: Departamento de Imunologia, Instituto de Microbiologia Prof. Paulo de Góes, CCS, Bloco I, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundao, 21941-970 Rio de Janeiro, RJ, Brazil. Phone and fax: (55-21) 560-8344. E-mail: imimlgl{at}microbio.ufrj.br.

Infection and Immunity, November 1999, p. 6177-6180, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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