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Infection and Immunity, November 1999, p. 6191-6193, Vol. 67, No. 11
National Institute of Child Health and Human
Development1 and National Institute of
Diabetes and Digestive and Kidney Diseases,4
National Institutes of Health, Bethesda, Maryland 20892-2720;
Tufts University School of Veterinary Medicine, Medford,
Massachusetts 015362; and Massachusetts
General Hospital, Boston, Massachusetts 021143
Received 18 May 1999/Returned for modification 29 June
1999/Accepted 9 August 1999
Escherichia coli O157 is the major cause of
diarrhea-associated hemolytic uremic syndrome (HUS). Strains causing
HUS contain either Shiga toxin 1 (Stx1) or Stx2, or both. In adult
volunteers, conjugate vaccines of detoxified lipopolysaccharide (LPS)
elicited bactericidal antibodies to E. coli O157. Here, the
detoxified LPS was conjugated with improved schemes to the nontoxic B
subunit of Stx1. Mice injected with these bivalent conjugates elicited both bactericidal antibodies to E. coli O157 and
neutralization antibodies to Stx1.
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Syntheses and Immunologic Properties of
Escherichia coli O157 O-Specific Polysaccharide and Shiga
Toxin 1 B Subunit Conjugates in Mice
*
Corresponding author. Mailing address: National
Institute of Child Health and Human Development, Room 424, Building 6, National Institutes of Health, Bethesda, MD 20892-2720. Phone: (301)
496-1185. Fax: (301) 402-9108. E-mail: scszu{at}helix.nih.gov.
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