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Infection and Immunity, November 1999, p. 6198-6202, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Superantigen Immune Stimulation Evokes Epithelial Monocyte Chemoattractant Protein 1 and RANTES Production

Sean Jedrzkiewicz,1 Galina Kataeva,1 Cory M. Hogaboam,2 Steven L. Kunkel,2 Robert M. Strieter,3 and Derek M. McKay1,*

Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada,1 and Departments of Pathology2 and Internal Medicine,3 University of Michigan, Ann Arbor, Michigan

Received 11 June 1999/Accepted 29 June 1999

Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Here we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus aureus enterotoxin B (SEB; a model SAg)-activated immune cells. Also, MCP-1 and RANTES mRNAs were increased in jejunal enterocytes isolated from SEB-treated mice. We suggest that T-cell recruitment to the gut following SAg immune activation could be partially due to epithelium-derived chemokines.

* Corresponding author. Mailing address: Intestinal Disease Research Programme, HSC-3N5, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5. Phone: (905) 525-9140, ext. 22588. Fax: (905) 522-3454. E-mail: mckayd{at}fhs.mcmaster.ca.

Infection and Immunity, November 1999, p. 6198-6202, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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