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Infection and Immunity, November 1999, p. 6203-6205, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of Neutrophil Apoptosis by Verotoxin 2 Derived from Escherichia coli O157:H7

Jiajia Liu, Tohru Akahoshi,* Takeshi Sasahana, Hidero Kitasato, Rie Namai, Takeji Sasaki, Matsuhisa Inoue, and Hirobumi Kondo

Department of Internal Medicine and Microbiology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228-8555, Japan

Received 6 July 1999/Returned for modification 30 July 1999/Accepted 20 August 1999

In order to evaluate the pathological role of verotoxin 2 (VT2), we investigated the effects of VT2 on neutrophil apoptosis in vitro. The results showed that VT2 caused a significant delay in spontaneous neutrophil apoptosis and that the effect was abrogated by a protein kinase C inhibitor. These data indicate that longer survival of neutrophils may aggravate neutrophil-mediated tissue damage in VT2-associated diseases.

* Corresponding author. Mailing address: Department of Internal Medicine and Microbiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. Phone: 42-778-9347. Fax: 42-778-8441. E-mail: akahoshi{at}med.kitasato-u.ac.jp.

Infection and Immunity, November 1999, p. 6203-6205, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.