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Infection and Immunity, November 1999, p. 6206-6209, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Urease-Based Mucosal Immunization against Helicobacter heilmannii Infection Induces Corpus Atrophy in Mice

Christine Dieterich,1 Hanifa Bouzourène,2 André L. Blum,1 and Irène E. Corthésy-Theulaz1,*

Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois,1 and Pathology Institute, Lausanne University,2 Lausanne, Switzerland

Received 22 July 1999/Accepted 24 August 1999

Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.

* Corresponding author. Mailing address: Division of Gastroenterology, Department of Internal Medicine, CHUV-BH19N.624, CH-1011 Lausanne, Switzerland. Phone: 41 21 314 06 85. Fax: 41 21 314 06 84. E-mail: Irene.Corthesy{at}CHUV.hospvd.CH.

Infection and Immunity, November 1999, p. 6206-6209, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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