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Infection and Immunity, November 1999, p. 6210-6212, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Anatomic Segmentation of the Intestinal Immune Response in Nonhuman Primates: Differential Distribution of B Cells after Oral and Rectal Immunizations to Sites Defined by Their Source of Vascularization

Kristina Eriksson,* Marianne Quiding-Järbrink, Jacek Osek,dagger Inger Nordström, Maria Hjulström, Jan Holmgren, and Cecil CzerkinskyDagger

Department of Medical Microbiology and Immunology, University of Göteborg, Göteborg, Sweden

Received 12 February 1999/Returned for modification 21 May 1999/Accepted 4 August 1999

We show that the distribution of specific antibodies and antibody-secreting cells in the intestine after oral and rectal immunizations corresponds to the vascularization and lymph drainage patterns of the gut. Oral immunizations induce antibody responses along the parts of the intestine connected to the superior mesenteric vessels and lymph ducts, whereas rectal immunizations induce antibody responses along the parts of the intestine associated with the inferior mesenteric vessels and ducts.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of Göteborg, Guldhedsgatan 10A, 413 46 Göteborg, Sweden. Phone: 46-31-604684. Fax: 46-31-820160. E-mail: Kristina.Eriksson{at}microbio.gu.se.

dagger Present address: National Veterinary Research Institute, Department of Microbiology, 24-100 Pulawy, Poland.

Dagger Present address: INSERM Unité 364, Faculté de Médecine-Pasteur, 06107 Nice Cedex 02, France.

Infection and Immunity, November 1999, p. 6210-6212, Vol. 67, No. 11
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.