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Infection and Immunity, December 1999, p. 6678-6682, Vol. 67, No. 12
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Theileria annulata in CD5+ Macrophages and B1 B Cells

Marie-Françoise Moreau,1 Jean-Laurent Thibaud,1 Leila Ben Miled,1,2 Marie Chaussepied,1 Martin Baumgartner,1 William C. Davis,3 Paola Minoprio,1 and Gordon Langsley1,*

URA CNRS 1960, Department of Immunology, Pasteur Institute, 75724 Paris Cedex 15, France1; Laboratory of Veterinary Science, Institut Pasteur BP 74 Tunis, Tunisia2; and Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington3

Received 16 March 1999/Returned for modification 16 April 1999/Accepted 19 August 1999

Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5+ clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5+ B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infections T. annulata can invade and transform CD5+ B cells.

* Corresponding author. Mailing address: URA CNRS 1960, Department of Immunology, Pasteur Institute, 25, Rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: (33-1) 45688922. Fax: (33-1) 40613185. E-mail: langsley{at}pasteur.fr.

Infection and Immunity, December 1999, p. 6678-6682, Vol. 67, No. 12
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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