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Infection and Immunity, February 1999, p. 484-489, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Natural Immunity to Ascaris lumbricoides Associated with Immunoglobulin E Antibody to ABA-1 Allergen and Inflammation Indicators in Children

Charles McSharry,1 Yu Xia,2,dagger Celia V. Holland,3 and Malcolm W. Kennedy2,*

Department of Immunology, University of Glasgow, Western Infirmary, Glasgow G11 6NT,1 and Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ,2 Scotland, United Kingdom, and Department of Zoology, Trinity College, Dublin 2, Ireland3

Received 10 August 1998/Returned for modification 1 October 1998/Accepted 11 November 1998

Children putatively immune to the large roundworm Ascaris lumbricoides were identified in an area of Nigeria where infection is hyperendemic. Immunity was associated with higher levels of serum ferritin, C-reactive protein, and eosinophil cationic protein, indicating ongoing acute phase or inflammatory processes. In contrast, children who were susceptible to the infection had little serological evidence of inflammation despite their high parasite burdens. Immunoglobulin G (IgG) antibody activity in all subclasses was present in high titer in most children but appeared to have no protective function. Despite exceptionally high total IgE levels, there was no evidence that atopic responses to local common allergens was associated with natural immunity to Ascaris. Among those individuals who produced IgG antibody to recombinant ABA-1 allergen of Ascaris, the naturally immune group had significantly more IgE antibody to the allergen than did those susceptible to the infection. IgE antibody responses in conjunction with innate inflammatory processes therefore appear to associate with natural immunity to ascariasis.

* Corresponding author. Mailing address: Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom. Phone: (44) 141 330 5819. Fax: (44) 141 330 4600. E-mail: malcolm.kennedy{at}bio.gla.ac.uk.

dagger Present address: Department of Pathology, School of Medicine, University of Louisville, Louisville, KY 40202.

Infection and Immunity, February 1999, p. 484-489, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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