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Infection and Immunity, February 1999, p. 972-975, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Pseudomonas aeruginosa Keratitis in Knockout Mice Deficient in Intercellular Adhesion Molecule 1

Jeffery A. Hobden,* Sharon Masinick-McClellan, Ronald P. Barrett, Kenneth S. Bark, and Linda D. Hazlett

Department of Anatomy and Cell Biology and Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201

Received 8 June 1998/Returned for modification 17 August 1998/Accepted 23 November 1998

In this study, the role of intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of Pseudomonas aeruginosa keratitis was examined by using inbred ICAM-1-deficient knockout mice. These mice had significantly less (P <=  0.02) ocular disease than wild-type mice, suggesting that ICAM-1 contributes to a more severe disease response following P. aeruginosa infection.

* Corresponding author. Mailing address: Wayne State University School of Medicine, Department of Immunology and Microbiology, 540 E. Canfield Ave., Detroit, MI 48201. Phone: (313) 577-9746. Fax: (313) 577-1155. E-mail: jhobden{at}med.wayne.edu.

Infection and Immunity, February 1999, p. 972-975, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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