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Infection and Immunity, February 1999, p. 986-988, Vol. 67, No. 2
Department of Microbiology,
Received 13 April 1998/Returned for modification 18 August
1998/Accepted 20 October 1998
Vaccination of mice with Escherichia coli expressing
Brucella Cu/Zn superoxide dismutase (SOD) [E.
coli(pBSSOD)] induced a significant level of protection
against virulent Brucella abortus challenge, although this
level was not as high as the one reached with B. abortus
vaccine strain RB51. In addition, vaccination with E. coli(pBSSOD) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro with a
thioredoxin-Cu/Zn SOD fusion protein.
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Vaccination with Live Escherichia coli Expressing
Brucella abortus Cu/Zn Superoxide Dismutase Protects
Mice against Virulent B. abortus
*
Corresponding author. Mailing address: Department of
Microbiology, Faculty of Biological Sciences, Universidad de
Concepción, P.O. Box 152-C, Concepción, Chile. Phone:
(056)-41-204118. Fax: (056)-41-245975. E-mail:
aonate{at}udec.cl.
Infection and Immunity, February 1999, p. 986-988, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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