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Infection and Immunity, February 1999, p. 998-1003, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

All Accessible Epitopes in the Salmonella Lipopolysaccharide Core Are Associated with Branch Residues

Ndubisi Anthony Nnalue*

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

Received 27 August 1998/Returned for modification 9 September 1998/Accepted 30 October 1998

Antisera generated against each of the nine known chemotypes of Salmonella lipopolysaccharide (LPS) core were characterized in order to delineate cross-reactive epitopes and define the bases for their accessibility. Strongly cross-reactive epitopes were associated with three chemotypes: Ra and Rb4, which recognized alpha -GlcNAc-1right-arrow2-alpha -Glc, and Rd1, which recognized L-alpha -D-heptose-1right-arrow7-L-alpha -D-heptose. Both these disaccharides and the more weakly cross-reactive alpha -Gal-1right-arrow6-alpha -Glc terminal in Rb3 LPS represent branch points along the core oligosaccharide. Therefore, branch points in endotoxin core oligosaccharides may generally be cross-reactive.

* Present address: Tonna Bioservices and Consulting, 8813 Allman Rd., Lenexa, KS 66219. Phone: (913) 894-9510. Fax: (913) 894-9528. E-mail: nnnalue{at}netscape.net.

Infection and Immunity, February 1999, p. 998-1003, Vol. 67, No. 2
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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