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Infection and Immunity, March 1999, p. 1521-1525, Vol. 67, No. 3
0019-9567/99

Correlation of Temperature and Toxicity in Murine Studies of Staphylococcal Enterotoxins and Toxic Shock Syndrome Toxin 1

Bradley G. Stiles,1,* Yvette G. Campbell,1 Robert M. Castle,1 and Sara A. Grove2

Department of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011,1 and Shippensburg University, Shippensburg, Pennsylvania 172572

Received 1 September 1998/Returned for modification 17 November 1998/Accepted 22 December 1998

This study describes a quick (<12 h) assay for detecting temperature decreases in BALB/c and C57BL/6 mice injected intraperitoneally (i.p.) with staphylococcal enterotoxin A (SEA), SEB, or SEC3 or toxic shock syndrome toxin 1 and a potentiating dose of lipopolysaccharide (LPS). Toxin-specific antisera effectively neutralized the temperature fluctuations in this model. Orally administered SEA or SEB (50 µg/animal), with or without LPS, did not have an effect on temperature or lethality. Versus wild-type mice, transgenic knockout mice lacking the p55 receptor for tumor necrosis factor (TNF) or gamma interferon were protected against an i.p. challenge of SEA plus LPS. The p75 receptor for TNF and intercellular adhesion molecule 1 have a negligible role in this toxic shock model.

* Corresponding author. Mailing address: Department of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Md. 21702-5011. Phone: (301) 619-4809. Fax: (301) 619-2348. E-mail: dr.bradleystiles{at}detrick.army.mil.

Infection and Immunity, March 1999, p. 1521-1525, Vol. 67, No. 3
0019-9567/99


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