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Infection and Immunity, April 1999, p. 1708-1714, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Protein H, an Antiphagocytic Surface Protein in Streptococcus pyogenes

Britt-Marie Kihlberg,* Mattias Collin, Arne Olsén, and Lars Björck

Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, Lund, Sweden

Received 19 June 1998/Returned for modification 26 August 1998/Accepted 17 December 1998

Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor H or factor H-like protein 1, which are regulatory proteins in the complement system, contribute to the antiphagocytic property.

* Corresponding author. Present address: Department of Cell and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden. Phone: 46-90-7852689. Fax: 46-90-771420. E-mail: Britt-Marie.Kihlberg{at}cmb.umu.se.

Infection and Immunity, April 1999, p. 1708-1714, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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