Previous Article | Next Article 
Infection and Immunity, April 1999, p. 1967-1973, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Genetic Control of Experimental Lyme Arthritis
in the Absence of Specific Immunity
Charles R.
Brown, and
Steven L.
Reiner*
Department of Medicine and Gwen Knapp Center
for Lupus and Immunology Research, Committee on Immunology,
University of Chicago, Chicago, Illinois 60637
Received 6 October 1998/Returned for modification 20 November
1998/Accepted 21 January 1999
Host genetics play an important role in determining resistance or
susceptibility to experimental Lyme arthritis. While specific immunity
appears to regulate disease resolution, innate immunity appears to
regulate disease severity. Intradermal infection with Borrelia
burgdorferi yields severe arthritis in C3H/He (C3H) mice but only
minimal arthritis in BALB/c mice. Intradermal infection of
immunodeficient C3H SCID mice also results in severe arthritis, but
arthritis of only moderate severity in BALB/c SCID mice. In the present
study, we examined immunodeficient recombinase-activating gene-knockout
(RAG-1
/
) (RAG
) mice from
resistant C57BL/6 (B6) and DBA/2 (DBA) mouse strains. B. burgdorferi-infected B6 RAG
and DBA
RAG
mice had little or no ankle swelling, a low
occurrence of inflammatory infiltrates in tibiotarsal joints, and low
arthritis severity scores in comparison to RAG+ and
RAG
BALB/c or C3H mice. Few differences in spirochete DNA
levels in ankles of resistant and susceptible RAG
mice
were seen. These data suggest that resistance to arthritis development
following B. burgdorferi infection is not necessarily dependent on an acquired immune response and can occur despite the
presence of high spirochete burden. Thus, genes expressed outside the
specific immune response can be central regulators of experimental arthritis.
*
Corresponding author. Mailing address: Gwen Knapp
Center for Lupus and Immunology Research, 924 E. 57th St., R422,
Chicago, IL 60637. Phone: (773) 702-4730. Fax: (773) 702-1576. E-mail: sreiner{at}midway.uchicago.edu.
Infection and Immunity, April 1999, p. 1967-1973, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
This article has been cited by other articles:
-
Miller, J. C., Ma, Y., Bian, J., Sheehan, K. C. F., Zachary, J. F., Weis, J. H., Schreiber, R. D., Weis, J. J.
(2008). A Critical Role for Type I IFN in Arthritis Development following Borrelia burgdorferi Infection of Mice. J. Immunol.
181: 8492-8503
[Abstract]
[Full Text]
-
Brown, C. R., Lai, A. Y.-C., Callen, S. T., Blaho, V. A., Hughes, J. M., Mitchell, W. J.
(2008). Adenoviral Delivery of Interleukin-10 Fails To Attenuate Experimental Lyme Disease. Infect. Immun.
76: 5500-5507
[Abstract]
[Full Text]
-
Iliopoulou, B. P., Alroy, J., Huber, B. T.
(2007). CD28 Deficiency Exacerbates Joint Inflammation upon Borrelia burgdorferi Infection, Resulting in the Development of Chronic Lyme Arthritis. J. Immunol.
179: 8076-8082
[Abstract]
[Full Text]
-
Crandall, H., Ma, Y., Dunn, D. M., Sundsbak, R. S., Zachary, J. F., Olofsson, P., Holmdahl, R., Weis, J. H., Weiss, R. B., Teuscher, C., Weis, J. J.
(2005). Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase. Am. J. Pathol.
167: 775-785
[Abstract]
[Full Text]
-
Behera, A. K., Hildebrand, E., Scagliotti, J., Steere, A. C., Hu, L. T.
(2005). Induction of Host Matrix Metalloproteinases by Borrelia burgdorferi Differs in Human and Murine Lyme Arthritis. Infect. Immun.
73: 126-134
[Abstract]
[Full Text]
-
Wang, X., Ma, Y., Weis, J. H., Zachary, J. F., Kirschning, C. J., Weis, J. J.
(2005). Relative Contributions of Innate and Acquired Host Responses to Bacterial Control and Arthritis Development in Lyme Disease. Infect. Immun.
73: 657-660
[Abstract]
[Full Text]
-
Brown, C. R., Blaho, V. A., Loiacono, C. M.
(2004). Treatment of Mice with the Neutrophil-Depleting Antibody RB6-8C5 Results in Early Development of Experimental Lyme Arthritis via the Recruitment of Gr-1- Polymorphonuclear Leukocyte-Like Cells. Infect. Immun.
72: 4956-4965
[Abstract]
[Full Text]
-
Liu, N., Montgomery, R. R., Barthold, S. W., Bockenstedt, L. K.
(2004). Myeloid Differentiation Antigen 88 Deficiency Impairs Pathogen Clearance but Does Not Alter Inflammation in Borrelia burgdorferi-Infected Mice. Infect. Immun.
72: 3195-3203
[Abstract]
[Full Text]
-
Glickstein, L., Moore, B., Bledsoe, T., Damle, N., Sikand, V., Steere, A. C.
(2003). Inflammatory Cytokine Production Predominates in Early Lyme Disease in Patients with Erythema Migrans. Infect. Immun.
71: 6051-6053
[Abstract]
[Full Text]
-
Aguilar-Delfin, I., Homer, M. J., Wettstein, P. J., Persing, D. H.
(2001). Innate Resistance to Babesia Infection Is Influenced by Genetic Background and Gender. Infect. Immun.
69: 7955-7958
[Abstract]
[Full Text]
-
Wang, G., Ojaimi, C., Iyer, R., Saksenberg, V., McClain, S. A., Wormser, G. P., Schwartz, I.
(2001). Impact of Genotypic Variation of Borrelia burgdorferi Sensu Stricto on Kinetics of Dissemination and Severity of Disease in C3H/HeJ Mice. Infect. Immun.
69: 4303-4312
[Abstract]
[Full Text]
-
Glickstein, L., Edelstein, M., Dong, J. Z.
(2001). Gamma Interferon Is Not Required for Arthritis Resistance in the Murine Lyme Disease Model. Infect. Immun.
69: 3737-3743
[Abstract]
[Full Text]
-
Diterich, I., Harter, L., Hassler, D., Wendel, A., Hartung, T.
(2001). Modulation of Cytokine Release in Ex Vivo-Stimulated Blood from Borreliosis Patients. Infect. Immun.
69: 687-694
[Abstract]
[Full Text]
-
Potter, M. R., Noben-Trauth, N., Weis, J. H., Teuscher, C., Weis, J. J.
(2000). Interleukin-4 (IL-4) and IL-13 Signaling Pathways Do Not Regulate Borrelia burgdorferi-Induced Arthritis in Mice: IgG1 Is Not Required for Host Control of Tissue Spirochetes. Infect. Immun.
68: 5603-5609
[Abstract]
[Full Text]
-
Brown, C. R., Reiner, S. L.
(2000). Bone-Marrow Chimeras Reveal Hemopoietic and Nonhemopoietic Control of Resistance to Experimental Lyme Arthritis. J. Immunol.
165: 1446-1452
[Abstract]
[Full Text]
-
Straubinger, R. K.
(2000). PCR-Based Quantification of Borrelia burgdorferi Organisms in Canine Tissues over a 500-Day Postinfection Period. J. Clin. Microbiol.
38: 2191-2199
[Abstract]
[Full Text]
-
Di Genaro, M. S., Munoz, E., Aguilera, C., de Guzman, A. M. S.
(2000). Yersinia enterocolitica O:8 and O:5 lipopolysaccharide arthritogenicity in hamsters. Rheumatology (Oxford)
39: 73-78
[Abstract]
[Full Text]
-
Brown, J. P., Zachary, J. F., Teuscher, C., Weis, J. J., Wooten, R. M.
(1999). Dual Role of Interleukin-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host Defense. Infect. Immun.
67: 5142-5150
[Abstract]
[Full Text]