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Infection and Immunity, April 1999, p. 2001-2004, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Adaptive Immune Response to Shigella flexneri 2a cydC in Immunocompetent Mice and Mice Lacking Immunoglobulin A

Sing Sing Way,1 Alain C. Borczuk,2 and Marcia B. Goldberg1,*

Department of Microbiology and Immunology1 and Department of Pathology,2 Albert Einstein College of Medicine, Bronx, New York 10461-1602

Received 2 November 1998/Returned for modification 15 December 1998/Accepted 14 January 1999

Shigella flexneri cydC, which is deficient in cytochrome bd, was rapidly cleared from the lungs of intranasally inoculated mice and was Sereny negative, yet it induced 93% protection against challenge with wild-type S. flexneri. Mice that lack immunoglobulin A (IgA) were fully protected, suggesting that IgA may not be required for adaptive immunity in this model system.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461-1602. Phone: (718) 430-2118. Fax: (718) 430-8711. E-mail: mgoldber{at}aecom.yu.edu.

Infection and Immunity, April 1999, p. 2001-2004, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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