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Infection and Immunity, April 1999, p. 2010-2012, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Vaccinated Mice Remain More Susceptible to Mycobacterium tuberculosis Infection Initiated via the Respiratory Route than via the Intravenous Route

Robert J. North,* Ronald LaCourse, and Lynn Ryan

The Trudeau Institute, Saranac Lake, New York 12983

Received 1 September 1998/Returned for modification 6 October 1998/Accepted 8 January 1999

Mice given Mycobacterium tuberculosis bacilli via the respiratory route succumbed much sooner to infection than mice given 1,000 times more bacilli via the intravenous route. Vaccination provided increased protection to an M. tuberculosis challenge infection; however, mice infected via the respiratory route remained much more susceptible.

* Corresponding author. Mailing address: The Trudeau Institute, 100 Algonquin Ave., Saranac Lake, NY 12983. Phone: (518) 891-3080. Fax: (518) 891-5126. E-mail: rjnorth{at}northnet.org.

Infection and Immunity, April 1999, p. 2010-2012, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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