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Infection and Immunity, April 1999, p. 2019-2021, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Alkaline Conditions Accelerate Polymorphonuclear Leukocyte Apoptosis In Vitro

Binnaz Leblebicioglu,1,2 and John Walters1,3,*

Sections of Periodontology,1 and Oral Biology,2 College of Dentistry, and Department of Medical Biochemistry, College of Medicine,3 The Ohio State University Health Sciences Center, Columbus, Ohio 43210

Received 5 October 1998/Returned for modification 24 November 1998/Accepted 19 January 1999

Apoptosis was monitored in polymorphonuclear leukocytes (PMNs) cultured under mildly acidic, neutral, and alkaline conditions. Within 3 h, 9.0% of the PMNs underwent apoptosis at pH 6.7, as did 12% at pH 7.2, 38% at pH 7.7, and 60% at pH 8.2. Inhibitors of serine proteases, caspase-1, or caspase-3 significantly inhibited PMN apoptosis at pH 8.2, suggesting an involvement by these enzymes.

* Corresponding author. Mailing address: College of Dentistry, The Ohio State University, 305 West 12th Ave., Columbus, OH 43210. Phone: (614) 292-1322. Fax: (614) 292-2438. E-mail: walters.2{at}osu.edu.

Infection and Immunity, April 1999, p. 2019-2021, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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