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Infection and Immunity, April 1999, p. 2019-2021, Vol. 67, No. 4
Sections of
Periodontology,1 and Oral
Biology,
Received 5 October 1998/Returned for modification 24 November
1998/Accepted 19 January 1999
Apoptosis was monitored in polymorphonuclear leukocytes (PMNs)
cultured under mildly acidic, neutral, and alkaline conditions. Within
3 h, 9.0% of the PMNs underwent apoptosis at pH 6.7, as did 12%
at pH 7.2, 38% at pH 7.7, and 60% at pH 8.2. Inhibitors of serine
proteases, caspase-1, or caspase-3 significantly inhibited PMN
apoptosis at pH 8.2, suggesting an involvement by these enzymes.
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Alkaline Conditions Accelerate Polymorphonuclear
Leukocyte Apoptosis In Vitro
*
Corresponding author. Mailing address: College of
Dentistry, The Ohio State University, 305 West 12th Ave., Columbus, OH
43210. Phone: (614) 292-1322. Fax: (614) 292-2438. E-mail:
walters.2{at}osu.edu.
Infection and Immunity, April 1999, p. 2019-2021, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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