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Infection and Immunity, April 1999, p. 2025-2029, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Clonal Expansion of Antigen-Specific CD4 T Cells following Infection with Salmonella typhimurium Is Similar in Susceptible (Itys) and Resistant (Ityr) BALB/c Mice

Zong-ming Chen, and Marc K. Jenkins*

Department of Microbiology and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Received 5 August 1998/Returned for modification 22 October 1998/Accepted 25 January 1999

The results show that CD4 T cells specific for a recombinant antigen expressed in Salmonella typhimurium proliferate normally in mice that express the susceptible form of the Ity gene at early times after infection but do not retain the capacity to produce gamma interferon later in the infection.


* Corresponding author. Mailing address: University of Minnesota Medical School, Department of Microbiology and the Center for Immunology, Box 334 UMHC, 420 Delaware St. S.E., Minneapolis, MN 55455. Phone: (612) 626-2715. Fax: (612) 625-2199. E-mail: marcj{at}lenti.med.umn.edu.


Infection and Immunity, April 1999, p. 2025-2029, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.



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