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Infection and Immunity, April 1999, p. 2035-2039, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of Exochelins of the Mycobacterium bovis Type Strain and BCG Substrains

Jovana Gobin,1 Diane K. Wong,2 Bradford W. Gibson,2 and Marcus A. Horwitz1,*

Department of Medicine, School of Medicine, University of California, Los Angeles, California 90095,1 and Department of Chemistry and Pharmaceutical Chemistry, University of California, San Francisco, California 94143-04462

Received 15 May 1998/Returned for modification 16 July 1998/Accepted 13 January 1999

Pathogenic mycobacteria must acquire iron in the host in order to multiply and cause disease. To do so, they release abundant quantities of siderophores called exochelins, which have the capacity to scavenge iron from host iron-binding proteins and deliver it to the mycobacteria. In this study, we have characterized the exochelins of Mycobacterium bovis, the causative agent of bovine and occasionally of human tuberculosis, and the highly attenuated descendant of M. bovis, bacillus Calmette-Guérin (BCG), widely used as a vaccine against human tuberculosis. The M. bovis type strain, five substrains of M. bovis BCG (Copenhagen, Glaxo, Japanese, Pasteur, and Tice), and two strains of virulent Mycobacterium tuberculosis all produce the same set of exochelins, although the relative amounts of individual exochelins may differ. Among these mycobacteria, the total amount of exochelins produced is greatest in M. tuberculosis, intermediate in M. bovis, and smallest in M. bovis BCG.

* Corresponding author. Mailing address: Department of Medicine, CHS 37-121, UCLA School of Medicine, 10833 LeConte Ave., Los Angeles, CA 90095. Phone: (310) 206-0074. Fax: (310) 794-7156. E-mail: MHorwitz{at}med1.medsch.ucla.edu.

Infection and Immunity, April 1999, p. 2035-2039, Vol. 67, No. 4
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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