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Infection and Immunity, May 1999, p. 2607-2610, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

A Murine Model for the Study of Chlamydia trachomatis Genital Infections during Pregnancy

Sukumar Pal, Ellena M. Peterson, and Luis M. de la Maza*

Department of Pathology, University of California, Irvine, Irvine, California 92697-4800

Received 7 October 1998/Returned for modification 10 November 1998/Accepted 4 February 1999

Pregnant BALB/c mice were inoculated intravaginally on day 5 of gestation with the Chlamydia trachomatis mouse pneumonitis biovar. Animals that received 105, 106, or 107 inclusion-forming units (IFU) of C. trachomatis delivered prematurely on days 15 to 16 of gestation. A focal inflammatory infiltrate was observed in the wall of the uterus on the day 14 of gestation in animals inoculated with 105 IFU. In this group of mice, immunohistochemical analysis showed chlamydial inclusions in the endometrium and fetal membranes.

* Corresponding author. Mailing address: Department of Pathology, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697-4800. Phone: (949) 824-7450. Fax: (949) 824-2160. E-mail: lmdelama{at}uci.edu.

Infection and Immunity, May 1999, p. 2607-2610, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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