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Infection and Immunity, May 1999, p. 2615-2618, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice

Bryan H. Bellaire,1 Philip H. Elzer,2 Cynthia L. Baldwin,3 and R. Martin Roop II1,*

Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, Louisiana 71130-39321; Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana 708032; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 010033

Received 21 September 1998/Returned for modification 19 November 1998/Accepted 29 January 1999

2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella, and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant (Delta entC) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130-3932. Phone: (318) 675-5771 (office) or (318) 675-5773 (lab). Fax: (318) 675-5764. E-mail: rroop{at}lsumc.edu.

Infection and Immunity, May 1999, p. 2615-2618, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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