This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Lisle, G. W.
Right arrow Articles by Buddle, B. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Lisle, G. W.
Right arrow Articles by Buddle, B. M.

 Previous Article  |  Next Article 

Infection and Immunity, May 1999, p. 2624-2626, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Vaccination of Guinea Pigs with Nutritionally Impaired Avirulent Mutants of Mycobacterium bovis Protects against Tuberculosis

Geoffrey W. de Lisle,* Theresa Wilson, Desmond M. Collins, and Bryce M. Buddle

AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand

Received 14 October 1998/Returned for modification 1 December 1998/Accepted 27 January 1999

Four nutritionally impaired strains of Mycobacterium bovis produced by illegitimate recombination were tested for their ability to protect guinea pigs against intratracheal challenge with virulent M. bovis. All four strains and M. bovis BCG induced significant levels of protection as measured by the reduced spread of infection to the spleen and liver. In animals vaccinated with BCG or two of the other strains, the bacterial counts from the lungs were significantly lower than those of the nonvaccinated animals.

* Corresponding author. Mailing address: AgResearch, Wallaceville Animal Research Centre, P.O. Box 40-063, Upper Hutt, New Zealand. Phone: 64 4 5286 089. Fax: 64 4 5281 380. E-mail: delisleg{at}agresearch.cri.nz.

Infection and Immunity, May 1999, p. 2624-2626, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Collins, D. M., Skou, B., White, S., Bassett, S., Collins, L., For, R., Hurr, K., Hotter, G., de Lisle, G. W. (2005). Generation of Attenuated Mycobacterium bovis Strains by Signature-Tagged Mutagenesis for Discovery of Novel Vaccine Candidates. Infect. Immun. 73: 2379-2386 [Abstract] [Full Text]  
  • Collins, D. M., Wilson, T., Campbell, S., Buddle, B. M., Wards, B. J., Hotter, G., de Lisle, G. W. (2002). Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures. Microbiology 148: 3019-3027 [Abstract] [Full Text]  
  • Wedlock, D. N., Vesosky, B., Skinner, M. A., de Lisle, G. W., Orme, I. M., Buddle, B. M. (2000). Vaccination of Cattle with Mycobacterium bovis Culture Filtrate Proteins and Interleukin-2 for Protection against Bovine Tuberculosis. Infect. Immun. 68: 5809-5815 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»