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Infection and Immunity, May 1999, p. 2656-2659, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of Staphylococcus epidermidis Polysaccharide Intercellular Adhesin/Hemagglutinin in the Pathogenesis of Intravascular Catheter-Associated Infection in a Rat Model

Mark E. Rupp,1,* Joseph S. Ulphani,1 Paul D. Fey,1 and Dietrich Mack2

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska,1 and Institute of Medical Microbiology and Immunology, University of Hamburg, Hamburg, Germany2

Received 30 November 1998/Returned for modification 7 January 1999/Accepted 9 February 1999

Biofilm production is thought to be a crucial factor in the ability of Staphylococcus epidermidis to produce a biomaterial-based infection. A rat central venous catheter (CVC)-associated infection model was used to assess the importance of biofilm production, mediated by polysaccharide intercellular adhesin/hemagglutinin (PIA/HA), in the pathogenesis of intravascular catheter-associated infection. PIA/HA-positive S. epidermidis 1457 was significantly more likely to cause a CVC-associated infection (71 versus 14%, P < 0.03) resulting in bacteremia and metastatic disease than its isogenic PIA/HA-negative mutant. These results confirm the importance of biofilm production, mediated by PIA/HA, in the pathogenesis of S. epidermidis experimental CVC-associated infection.

* Corresponding author. Mailing address: Department of Internal Medicine, University of Nebraska Medical Center, 600 S. 42nd St., Omaha, NE 68198-5400. Phone: (402) 559-8650. Fax: (402) 559-5581. E-mail: MERUPP{at}UNMC.EDU.

Infection and Immunity, May 1999, p. 2656-2659, Vol. 67, No. 5
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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