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Infection and Immunity, June 1999, p. 3061-3065, Vol. 67, No. 6
Departments of Oral
Bacteriology,1 Oral Anatomy
I,2 and Prosthetic
Dentistry,3 Hokkaido University School of
Dentistry, Kita-Ku, Sapporo 060-8586, Japan
Received 21 December 1998/Returned for modification 15 February
1999/Accepted 26 March 1999
Lipoproteins in the cell membranes of both Mycoplasma
salivarium and Mycoplasma fermentans were
demonstrated to trigger the transcription of intercellular adhesion
molecule-1 mRNA in normal fibroblasts isolated from human gingival
tissue and to induce its cell surface expression by a mechanism
distinct from that of Escherichia coli lipopolysaccharide.
The lipid moiety of the lipoproteins was suggested to play a key role
in the expression of the activity.
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Transcriptional Activation of mRNA of Intercellular Adhesion
Molecule 1 and Induction of Its Cell Surface Expression in Normal
Human Gingival Fibroblasts by Mycoplasma salivarium and
Mycoplasma fermentans
*
Corresponding author. Mailing address: Department of
Oral Bacteriology, Hokkaido University School of Dentistry, Nishi 7, Kita 13, Kita-Ku, Sapporo 060-8586, Japan. Phone: 011-706-4241. Fax:
011-706-4901. E-mail: shibaken{at}den.hokudai.ac.jp.
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