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Infection and Immunity, June 1999, p. 3135-3140, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Analysis of Vaginal Cell Populations during Experimental Vaginal Candidiasis

Paul L. Fidel Jr.,* Wei Luo, Chad Steele, Joseph Chabain, Marc Baker, and Floyd Wormley Jr.

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana

Received 16 October 1998/Returned for modification 6 December 1998/Accepted 20 February 1999

Studies with an estrogen-dependent murine model of vaginal candidiasis suggest that local cell-mediated immunity (CMI) is more important than systemic CMI for protection against vaginitis. The present study, however, showed that, compared to uninfected mice, little to no change in the percentage or types of vaginal T cells occurred during a primary vaginal infection or during a secondary vaginal infection where partial protection was observed. Furthermore, depletion of polymorphonuclear leukocytes (PMN) had no effect on infection in the presence or absence of pseudoestrus. These results indicate a lack of demonstrable effects by systemic CMI or PMN against vaginitis and suggest that if local T cells are important, they are functioning without showing significant increases in numbers within the vaginal mucosa during infection.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, 1901 Perdido St., New Orleans, LA 70112. Phone: (504) 568-4066. Fax: (504) 568-4066. E-mail: pfidel{at}lsumc.edu.

Infection and Immunity, June 1999, p. 3135-3140, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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