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Infection and Immunity, June 1999, p. 3146-3150, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Stability of erp Loci during Borrelia burgdorferi Infection: Recombination Is Not Required for Chronic Infection of Immunocompetent Mice

Nazira El Hage,1 Louis D. Lieto,2 and Brian Stevenson1,*

Department of Microbiology and Immunology, University of Kentucky College of Medicine, Lexington, Kentucky, 40536-0084,1 and Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40536-00762

Received 15 December 1998/Returned for modification 26 February 1999/Accepted 4 March 1999

Borrelia burgdorferi can persistently infect mammals despite their production of antibodies directed against bacterial proteins, including the Erp lipoproteins. We sequenced erp loci of bacteria reisolated from laboratory mice after 1 year of infection and found them to be identical to those of the inoculant bacteria. We conclude that recombination of erp genes is not essential for chronic mammalian infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, MS415 Chandler Medical Center, University of Kentucky College of Medicine, Lexington, KY 40536-0084. Phone: (606) 257-9358. Fax: (606) 257-8994. E-mail: bstev0{at}pop.uky.edu.

Infection and Immunity, June 1999, p. 3146-3150, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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