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Infection and Immunity, June 1999, p. 3151-3154, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Macrophages and Epithelial Cells Respond Differently to the Pseudomonas aeruginosa Type III Secretion System

Jenifer Coburn,1,* and Dara W. Frank2

Division of Rheumatology and Immunology, Tufts-New England Medical Center, Boston, Massachusetts 02111,1 and Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin 532262

Received 16 March 1999/Accepted 2 April 1999

The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.

* Corresponding author. Mailing address: Division of Rheumatology and Immunology, Tufts-New England Medical Center, Box 406, 750 Washington St., Boston, MA 02111. Phone: (617) 636-5952. Fax: (617) 636-4252. E-mail: jcoburn_bor{at}opal.tufts.edu.

Infection and Immunity, June 1999, p. 3151-3154, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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