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Infection and Immunity, June 1999, p. 3155-3159, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Early Gene Expression of NK Cell-Activating Chemokines in Mice Resistant to Leishmania major

Bettina Vester,1 Kerstin Müller,2 Werner Solbach,2 and Tamás Laskay2,*

Institute for Clinical Microbiology and Immunology, University of Erlangen-Nürnberg, Erlangen,1 and Institute for Medical Microbiology and Hygiene, Medical University of Lübeck, Lübeck,2 Germany

Received 5 August 1998/Returned for modification 22 September 1998/Accepted 22 March 1999

Susceptibility of mice to Leishmania major is associated with an insufficient NK cell-mediated innate immune response. We analyzed the expression of NK cell-activating chemokines in vivo during the first days of infection in resistant and susceptible mice. The mRNA expression of gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and lymphotactin was upregulated 1 day after infection in the draining lymph nodes of resistant C57BL/6 mice but not in those of susceptible BALB/c mice. In vivo local treatment of BALB/c mice with recombinant IP-10 shortly after infection resulted in an enhanced NK cell activity in the draining lymph node. The data suggest that although the recruitment of NK cells is normal in susceptible mice, the lack of NK cell-activating chemokines is a factor resulting in a suboptimal NK cell-mediated defense.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Hygiene, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. Phone: 49-451-500-2817. Fax: 49-451-500-2808. E-mail: laskay{at}hygiene.mu-luebeck.de.

Infection and Immunity, June 1999, p. 3155-3159, Vol. 67, No. 6
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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