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Infection and Immunity, July 1999, p. 3334-3338, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

T-Cell Responses during Trypanosoma brucei Infections in Mice Deficient in Inducible Nitric Oxide Synthase

Amanda E. Millar,1,dagger Jerry Sternberg,2 Charlie McSharry,3 Xiao-Qing Wei,3 F. Y. Liew,3 and C. Michael R. Turner1,*

Division of Infection & Immunity, I.B.L.S., University of Glasgow, Glasgow G12 8QQ,1 Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ,2 and Department of Immunology, University of Glasgow, Glasgow G11 6NT,3 United Kingdom

Received 28 August 1998/Returned for modification 28 January 1999/Accepted 5 April 1999

We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak parasitemia values were the same in both groups. However, the heterozygous mice maintained higher parasitemia levels after the peak of an infection than the homozygous mice due to a decrease in the rate of clearance of parasites. In iNOS-deficient mice there was an increase in the numbers of total CD4+ cells and activated (interleukin-2 receptor-expressing) CD4+ cells in infected mice compared with the numbers in uninfected mice. Spleen cells from infected iNOS-deficient mice displayed increased proliferative responses and gamma interferon secretion when stimulated in vitro than those of control mice. These data suggest that NO production depresses T-helper 1-like responses generated during Trypanosoma brucei infections, thus promoting the survival of the parasite.

* Corresponding author. Mailing address: Division of Infection & Immunity, I.B.L.S., Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom. Phone: (44) 141-330-6629. Fax: (44) 141-330-3516. E-mail: m.turner{at}bio.gla.ac.uk.

dagger Present address: Department of Pediatrics, University of Washington, Seattle, WA 98195.

Infection and Immunity, July 1999, p. 3334-3338, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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