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Infection and Immunity, July 1999, p. 3424-3429, Vol. 67, No. 7
0019-9567/99/$04.00+0

Interleukin-10 Responses to Liver-Stage Antigen 1 Predict Human Resistance to Plasmodium falciparum

Jonathan D. Kurtis,1,dagger David E. Lanar,2 Malachi Opollo,1 and Patrick E. Duffy1,*

U.S. Army Medical Research Unit-Kenya and Kenya Medical Research Institute, Kisumu, Kenya,1 and Walter Reed Army Institute of Research, Washington, D.C.2

Received 12 January 1999/Returned for modification 23 February 1999/Accepted 14 April 1999

The design of an effective vaccine against Plasmodium falciparum, the most deadly malaria parasite of humans, requires a careful definition of the epitopes and the immune responses involved in protection. Liver-stage antigen 1 (LSA-1) is specifically expressed during the hepatic stage of P. falciparum and elicits cellular and humoral immune responses in naturally exposed individuals. We report here that interleukin-10 (IL-10) production in response to LSA-1 predicts resistance to P. falciparum after eradication therapy. Resistance was not related to gamma interferon or tumor necrosis factor alpha production. This is the first report that human IL-10 responses are associated with resistance after eradication therapy, and our findings support the inclusion of LSA-1 in a vaccine against malaria.

* Corresponding author. Present address: Room 2028, Immunology, Building 40, Walter Reed Army Institute of Research, 14th & Dahlia St., Washington, DC 20307-5100. Phone: (202) 782-1234 or (202) 782-0200. Fax: (202) 782-0748. E-mail: duffyp{at}wrsmtp-ccmail.army.mil.

dagger Present address: Hospital of the University of Pennsylvania, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104.

Infection and Immunity, July 1999, p. 3424-3429, Vol. 67, No. 7
0019-9567/99/$04.00+0


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