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Infection and Immunity, July 1999, p. 3641-3644, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

CD4+ T Cells Which React to the Leishmania major LACK Antigen Rapidly Secrete Interleukin-4 and Are Detrimental to the Host in Resistant B10.D2 Mice

Valérie Julia, and Nicolas Glaichenhaus*

Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France

Received 16 February 1999/Returned for modification 19 March 1999/Accepted 14 April 1999

Leishmania major induces the rapid production of interleukin-4 (IL-4) in both susceptible BALB/c and resistant B10.D2 mice. In both strains, IL-4 is produced by T cells which react to the parasite LACK (for Leishmania homolog of the receptor for activated C kinase) antigen. The rapid production of IL-4 in B10.D2 mice does not confer susceptibility but results in increased parasite burdens.

* Corresponding author. Mailing address: Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Groupement de Recherche en Parasitologie (GDR), 660 Route des Lucioles, 06560 Valbonne, France. Phone: 33 4 93 95 77 85. Fax: 33 4 93 95 77 08. E-mail: glaichenhaus{at}ipmc.cnrs.fr.

Infection and Immunity, July 1999, p. 3641-3644, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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