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Infection and Immunity, July 1999, p. 3670-3673, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Human Monocytic U937 Cells Kill Salmonella In Vitro by NO-Independent Mechanisms

Päivi Ekman,1,* Marja Saarinen,1 Qiushui He,1,2 Mika Virtala,1 Marko Salmi,1 and Kaisa Granfors1

National Public Health Institute, Department in Turku,1 and Department of Pediatrics, University of Turku,2 Turku, Finland

Received 12 November 1998/Returned for modification 18 February 1999/Accepted 6 April 1999

Nitric oxide (NO) has a central role in host defense against intracellular microbes. HLA-B27 has been shown to directly modulate host-microbe interaction in vitro, leading to the impaired elimination of Salmonella in human monocytic U937 cells. Here, we studied whether impaired elimination of Salmonella would result from differences in NO production between HLA-B27- and HLA-A2-transfected U937 cells. Both human monocytic transfectants produced NO equally well and killed Salmonella via NO-independent mechanisms.

* Corresponding author. Mailing address: National Public Health Institute, Kiinamyllynkatu 13, FIN-20520 Turku, Finland. Phone: 358-2-2519 255. Fax: 358-2-2519 254. E-mail: pailai{at}utu.fi.

Infection and Immunity, July 1999, p. 3670-3673, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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