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Infection and Immunity, July 1999, p. 3686-3689, Vol. 67, No. 7
0019-9567/99/$04.00+0

Chlamydial Colonization of Multiple Mucosae following Infection by Any Mucosal Route

Linda L. Perry,* and Scott Hughes

Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840

Received 12 February 1999/Returned for modification 12 March 1999/Accepted 20 April 1999

Chlamydia trachomatis inoculated by any mucosal route colonized multiple murine mucosae and, in most cases, the spleen, liver, and kidneys. Cell-to-cell transmission, systemic dissemination, and autoinoculation of infectious fluids may have contributed to chlamydial spread. Intermucosal trafficking of protective T cells cannot be accurately evaluated by using live chlamydial challenges.

* Corresponding author. Mailing address: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th St., Hamilton, MT 59840. Phone: (406) 363-9272. Fax: (406) 363-9380.

Infection and Immunity, July 1999, p. 3686-3689, Vol. 67, No. 7
0019-9567/99/$04.00+0


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