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Infection and Immunity, August 1999, p. 3915-3920, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Selective Distribution of a High-Affinity Plasminogen-Binding Site among Group A Streptococci Associated with Impetigo

Mikael D. Svensson,1 Ulf Sjöbring,1,* and Debra E. Bessen2,*

Department of Laboratory Medicine, Lund University, Lund, Sweden,1 and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut2

Received 14 January 1999/Returned for modification 8 April 1999/Accepted 28 May 1999

Group A streptococci can be classified according to their tendency to cause either impetigo, pharyngitis, or both types of infection. Genotypic markers for tissue site preference lie within emm genes, which encode fibrillar surface proteins that play a key role in virulence. emm gene products (M and M-like proteins) display an extensive array of binding activities for tissue and plasma proteins of the human host. In a previous study, a high-affinity binding site for human plasmin(ogen) was mapped to the emm53 gene product. In this report, a structurally similar plasminogen-binding domain is found to be widely and selectively distributed among group A streptococci harboring the emm gene marker for the skin as the preferred tissue site for infection. The findings are highly suggestive of a central role for bacterial modulation of host plasmin(ogen) during localized infection at the epidermis.

* Corresponding author. Mailing address for Ulf Sjöbring: Lund University, Department of Laboratory Medicine, Solvegatan 23, 223 62 Lund, Sweden. Phone: 46-46-173238. Fax: 46-46-189117. E-mail: Ulf.Sjobring{at}mig.lu.se. Mailing address for Debra E. Bessen: Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College St., Box 208034, New Haven, CT 06520. Phone: (203) 785-4480. Fax: (203) 737-4285. E-mail: debra.bessen{at}yale.edu.

Infection and Immunity, August 1999, p. 3915-3920, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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