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Infection and Immunity, August 1999, p. 3970-3979, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Thymic Independence of Adaptive Immunity to the Intracellular Pathogen Shigella flexneri Serotype 2a

Sing Sing Way,1 Alain C. Borczuk,2,dagger and Marcia B. Goldberg1,*

Department of Microbiology and Immunology,1 and Department of Pathology,2 Albert Einstein College of Medicine, Bronx, New York 10461-1602

Received 2 February 1999/Returned for modification 31 March 1999/Accepted 19 May 1999

Shigella flexneri is a facultative intracellular pathogen. While immunity to several intracellular pathogens is mediated by T lymphocytes, it is unknown whether cellular immune responses are important to adaptive immunity to S. flexneri. We show that vaccination with S. flexneri serotype 2a confers protection to mice that lack T lymphocytes or gamma interferon (IFN-gamma ), specific depletion of T lymphocytes does not alter the protection, and adoptive transfer of splenocytes from vaccinated mice does not confer protection to naive mice. In contrast, vaccination conferred no protection to mice that lack B lymphocytes and adoptive transfer of immune sera conferred partial protection to naive mice. These data demonstrate that in the mouse bronchopulmonary model, adaptive immunity to S. flexneri 2a is an antibody-mediated, B-lymphocyte-dependent process and can be generated in the absence of T lymphocytes or IFN-gamma .

* Corresponding author. Present address: Division of Infectious Disease, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114. Phone: (617) 726-3812. Fax: (617) 726-7416.

dagger Present address: Department of Laboratories, North Shore University Hospital, Manhasset, NY 11030.

Infection and Immunity, August 1999, p. 3970-3979, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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