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Infection and Immunity, August 1999, p. 4149-4152, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Myeloperoxidase Exerts Microbicidal Activity against Mycobacterium tuberculosis

Violetta Borelli,1 Elena Banfi,2 Maria Giovanna Perrotta,1 and Giuliano Zabucchi1,*

Dipartimento di Fisiologia e Patologia1 and Dipartimento di Scienze Biomediche,2 Università di Trieste, 34127 Trieste, Italy

Received 22 January 1999/Returned for modification 22 March 1999/Accepted 18 May 1999

We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.

* Corresponding author. Mailing address: Dipartimento di Fisiologia e Patologia, Università di Trieste, Via A. Fleming 22, 34127 Trieste, Italy. Phone: 39 40 6763700, 6767179. Fax: 39 40 567862. E-mail: zabucchi{at}fc.univ.trieste.it.

Infection and Immunity, August 1999, p. 4149-4152, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Borelli, V., Vita, F., Shankar, S., Soranzo, M. R., Banfi, E., Scialino, G., Brochetta, C., Zabucchi, G. (2003). Human Eosinophil Peroxidase Induces Surface Alteration, Killing, and Lysis of Mycobacterium tuberculosis. Infect. Immun. 71: 605-613 [Abstract] [Full Text]  
  • Ashitani, J.-i., Mukae, H., Hiratsuka, T., Nakazato, M., Kumamoto, K., Matsukura, S. (2002). Elevated Levels of {alpha}-Defensins in Plasma and BAL Fluid of Patients With Active Pulmonary Tuberculosis. Chest 121: 519-526 [Abstract] [Full Text]  


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