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Infection and Immunity, August 1999, p. 4268-4271, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Identification of Genes Encoding Two-Component Lantibiotic Production in Staphylococcus aureus C55 and Other Phage Group II S. aureus Strains and Demonstration of an Association with the Exfoliative Toxin B Gene

Maduwe A. D. B. Navaratna,1 Hans-Georg Sahl,2 and John R. Tagg1,*

Department of Microbiology, University of Otago, Dunedin, New Zealand,1 and Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, D-53105 Bonn, Germany2

Received 3 November 1998/Returned for modification 8 April 1999/Accepted 17 May 1999

The production of exfoliative toxin B (ET-B), but not ET-A, was shown to be specifically associated with production of a highly conserved two-component lantibiotic peptide system in phage group II Staphylococcus aureus. Two previously studied but incompletely characterized S. aureus bacteriocins, staphylococcins C55 and BacR1, were found to be members of this lantibiotic system, and considerable homology was also found with the two-component Lactococcus lactis bacteriocin, lacticin 3147. sacalpha A and sacbeta A, the structural genes of the lantibiotics staphylococcins C55alpha and C55beta and two putative lantibiotic processing genes, sacM1 and sacT, were localized together with the ET-B structural gene to a single 32-kb plasmid in strain C55. Irreversible loss of both ET-B and two-component lantibiotic production occurs during laboratory passage of ET-B-positive S. aureus strains, particularly at elevated temperatures.

* Corresponding author. Mailing address: Department of Microbiology, University of Otago, Dunedin, New Zealand. Phone: 64 3 479 7714. Fax: 64 3 479 8540. E-mail: john.tagg{at}stonebow.otago.ac.nz.

Infection and Immunity, August 1999, p. 4268-4271, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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