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Infection and Immunity, August 1999, p. 4295-4297, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Elevated Chemokine Concentrations in Sera of Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Patients with Tuberculosis: a Possible Role for Mycobacterial Lipoarabinomannan

Nicole P. Juffermans,1,2,* Annelies Verbon,2 Sander J. H. van Deventer,1 Henk van Deutekom,3 John T. Belisle,4 Michael E. Ellis,4 Peter Speelman,2 and Tom van der Poll1,2

Laboratory of Experimental Internal Medicine1 and Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS,2 Academic Medical Center, University of Amsterdam, and Department of Tuberculosis, Municipal Health Service,3 Amsterdam, The Netherlands, and Department of Microbiology, Colorado State University, Fort Collins, Colorado4

Received 9 February 1999/Returned for modification 24 March 1999/Accepted 27 May 1999

Levels of interleukin 8 (IL-8), gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1beta (MIP-1beta ) were elevated in patients with tuberculosis. IP-10 and MCP-1 levels were higher in human immunodeficiency virus (HIV)-seropositive patients than in HIV-seronegative patients with tuberculosis. Lipoarabinomannan induced IL-8, MCP-1, and MIP-1beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody.

* Corresponding author. Mailing address: Laboratory of Experimental Medicine, Room G2-105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5666034. Fax: 31-20-6977192. E-mail: N.Juffermans{at}amc.uva.nl.

Infection and Immunity, August 1999, p. 4295-4297, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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