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Infection and Immunity, September 1999, p. 4921-4925, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Role of Local Cytokines in Increased Gastric Expression of the Secretory Component in Helicobacter pylori Infection

Ingela Ahlstedt,1 Catharina Lindholm,1 Hans Lönroth,2 Annika Hamlet,1,2 Ann-Mari Svennerholm,1 and Marianne Quiding-Järbrink1,*

Departments of Medical Microbiology and Immunology1 and of Surgery,2 Göteborg University, Göteborg, Sweden

Received 23 December 1998/Returned for modification 15 February 1999/Accepted 16 June 1999

Using immunohistochemical staining, we examined the presence of secretory component (SC) on epithelial cells in gastric and duodenal biopsy specimens collected from Helicobacter pylori-infected individuals and healthy controls. Gastric epithelial cells from healthy volunteers expressed low, but detectable, levels of SC. In contrast, significantly higher level of expression of SC (P < 0.001) was observed on epithelial cells in the antra of H. pylori-infected individuals. The antral SC expression correlated with staining for gamma interferon of intraepithelial and lamina propria lymphocytes (rs = 0.76 and 0.69, respectively, P < 0.001) and correlated weakly with production of tumor necrosis factor alpha (rs = 0.43, P < 0.05), but it did not correlate at all with interleukin-4 production.

* Corresponding author. Mailing address: Dept. of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Phone: 44-171-927 2257. Fax: 44-171-323 5687. E-mail: m.quiding{at}lshtm.ac.uk.

Infection and Immunity, September 1999, p. 4921-4925, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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