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Infection and Immunity, September 1999, p. 4939-4944, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Coinfection with Toxoplasma gondii Inhibits Antigen-Specific Th2 Immune Responses, Tissue Inflammation, and Parasitism in BALB/c Mice Infected with Leishmania major

H. C. Santiago,1 M. A. P. Oliveira,1 E. A. Bambirra,2 A. M. C. Faria,1 L. C. C. Afonso,3 L. Q. Vieira,1 and R. T. Gazzinelli1,4,*

Department of Biochemistry and Immunology---ICB1 and Department of Pathologic Anatomy---Medical School,2 Federal University of Minas Gerais, 31270-910 Belo Horizonte, Centro de Pesquisas René Rachou, FIOCRUZ, 30190-002 Belo Horizonte,4 and Department of Biological Sciences---NUPEB, Federal University of Ouro Preto, 35400-000 Ouro Preto,3 Minas Gerais, Brazil

Received 15 March 1999/Returned for modification 16 April 1999/Accepted 9 June 1999

Lesion size, cellular infiltration, and tissue parasitism in the footpads of BALB/c mice infected with Leishmania major were all dramatically inhibited during acute but not chronic infection with Toxoplasma gondii. Similarly, acute but not chronic toxoplasmosis at the time of infection with L. major had a strong inhibitory effect on development of acquired immune responses mediated by Th2 lymphocytes. In contrast, no major changes in Leishmania-specific Th1-mediated responses were observed in mice coinfected with T. gondii.

* Corresponding author. Mailing address: Department of Biochemistry and Immunology, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil. Phone: 031 295 3566. Fax: 031 295 3115. E-mail: ritoga{at}mono.icb.ufmg.br.

Infection and Immunity, September 1999, p. 4939-4944, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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