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Infection and Immunity, September 1999, p. 4950-4954, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Differential Regulation of Enteric and Systemic Salmonellosis
by slyA
Patricia R.
Watson,1
Sue M.
Paulin,1
A. Patricia
Bland,1
Stephen J.
Libby,2
Philip W.
Jones,1 and
Tim S.
Wallis1,*
Institute for Animal Health, Compton,
Newbury, Berkshire RG20 7NN, United Kingdom,1
and Department of Microbiology, North Carolina State
University, Raleigh, North Carolina 27695-76152
Received 8 June 1999/Returned for modification 18 June
1999/Accepted 25 June 1999
Mutation of slyA, which reduces Salmonella
typhimurium virulence in mice, caused only minor attenuation of
S. typhimurium virulence in orally inoculated calves. This
correlated with modest reductions in intestinal invasion and
enteropathogenic responses in bovine ligated ileal loops.
slyA appears to regulate virulence genes involved in
systemic, but not enteric, salmonellosis.
*
Corresponding author. Mailing address: Institute for
Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: (1635) 578411. Fax: (1635) 577243. E-mail:
timothy.wallis{at}bbsrc.ac.uk.
Infection and Immunity, September 1999, p. 4950-4954, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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