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Infection and Immunity, September 1999, p. 4950-4954, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Differential Regulation of Enteric and Systemic Salmonellosis by slyA

Patricia R. Watson,1 Sue M. Paulin,1 A. Patricia Bland,1 Stephen J. Libby,2 Philip W. Jones,1 and Tim S. Wallis1,*

Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom,1 and Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695-76152

Received 8 June 1999/Returned for modification 18 June 1999/Accepted 25 June 1999

Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to regulate virulence genes involved in systemic, but not enteric, salmonellosis.

* Corresponding author. Mailing address: Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: (1635) 578411. Fax: (1635) 577243. E-mail: timothy.wallis{at}bbsrc.ac.uk.

Infection and Immunity, September 1999, p. 4950-4954, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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