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Infection and Immunity, September 1999, p. 4960-4962, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Outer Membrane Proteins Omp10, Omp16, and Omp19 of Brucella spp. Are Lipoproteins

Anne Tibor,* Béatrice Decelle, and Jean-Jacques Letesson

Laboratoire de Microbiologie et d'Immunologie, Facultés Universitaires Notre-Dame de la Paix, B-5000 Namur, Belgium

Received 22 February 1999/Returned for modification 11 May 1999/Accepted 15 June 1999

The deduced sequences of the Omp10, Omp16, and Omp19 outer membrane proteins of Brucella spp. contain a potential bacterial lipoprotein processing sequence. After extraction with Triton X-114, these three proteins partitioned into the detergent phase. Processing of the three proteins is inhibited by globomycin, a specific inhibitor of lipoprotein signal peptidase. The three proteins were radioimmunoprecipitated from [3H]palmitic acid-labeled Brucella abortus lysates with monoclonal antibodies. These results demonstrate that Omp10, Omp16, and Omp19 are lipoproteins.

* Corresponding author. Mailing address: Laboratoire de Microbiologie et d'Immunologie, Facultés Universitaires Notre-Dame de la Paix, rue de Bruxelles 61, B-5000 Namur, Belgium. Phone: 32 81 72 44 44. Fax: 32 81 72 44 20. E-mail: anne.tibor{at}fundp.ac.bc.

Infection and Immunity, September 1999, p. 4960-4962, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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