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Infection and Immunity, September 1999, p. 4974-4976, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Experimental Transmission of Neisseria gonorrhoeae from Pregnant Rat to Fetus

Stella Nowicki,1,2,* Rangaraj Selvarangan,1,2 and Garland Anderson1

Division of Infectious Diseases, Department of Obstetrics & Gynecology,1 and Department of Microbiology and Immunology,2 The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1062

Received 16 February 1999/Returned for modification 16 April 1999/Accepted 15 June 1999

Sprague-Dawley rats were infected on day 20 of pregnancy by intraperitoneal inoculation with Neisseria gonorrhoeae. Disseminated gonococcal infection (DGI) and pelvic inflammatory disease (PID) strains in the presence of C1q but not in the presence of bovine serum albumin (BSA) were able to spread from the pregnant rat to the fetus and resulted in fetal mortality. Transmission of DGI and PID strains that are serum resistant (serr) and sac-4 positive but not of a local infection strain that is sers and sac-4 negative was facilitated by the C1q-dependent mechanism. This study provides the first experimental model that may mimic the transmission of gonococcal infection from mother to the fetus during pregnancy.

* Corresponding author. Mailing address: Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555-1062. Phone: (409) 772-7598. Fax: (409) 747-0475. E-mail: snowicki{at}utmb.edu.

Infection and Immunity, September 1999, p. 4974-4976, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.